With click chemistry towards easy, fast and reliable nucleic acid bioconjugation

Your research projects and product developments have already enough critical points and issues to be solved. Labeling or bioconjugation should not become one of them! Instead you should be able to concentrate on your real research target. Therefore, Baseclick has invented a very simple and straight forward technique to label your biological samples using click chemistry tools and offer you various products, all based on this versatile azide-alkyne reaction.

Applying this efficient technology to your DNA and RNA applications, labelling will be straightforward. Baseclick offers the best-in-class click chemistry tools for emerging applications. The most popular example is EdU (5-ethynyl-2’-deoxyuridine) cell proliferation assay. This click assay shows several advantages over other cell viability assays (BrdU or 3H-thymidine) making it a superior evaluation tool for monitoring genotoxicity, evaluation of anticancer drugs or cell cycle analysis and for assessing cell vitality. Due to direct measurement of cell proliferation our assay is thus highly reliable and showing no toxic effects in animals. As it is incorporated into DNA during active DNA synthesis and shows a clickable functionality, the content of new cells can be assessed after harvesting the tissue of interest. Detection can then be performed after reaction with the dye of choice, using 3 standard fluorescent readouts: microscopic imaging, flow cytometry or HTS.

Imaging

Flow Cytometry

High Throughput Screening

COVID19 qPCR Primers

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