Cell proliferation kits for imaging

All EdU based proliferation kits on the market are patented by Baseclick since 2007. This click assay shows several advantages over other cell viability assays (BrdU or 3H-thymidine) making it a superior evaluation tool for monitoring genotoxicity, evaluation of anticancer drugs or cell cycle analysis and for assessing cell vitality. Due to direct measurement of cell proliferation our assay is thus highly reliable and showing no toxic effects in animals. A differentiation between cells that are actively dividing and those that are quiescent is herewith possible. Measured are only the cells in vitro or in vivo that are actively dividing. Healthy cells that are not dividing are not detected and can thus give no false positives. The patented technique is based on the incorporation of the thymidine analogue EdU, an alkyne modified nucleoside, in DNA during active cell synthesis in whole animals. After incorporation, EdU is detected via click chemistry in different organs. In healthy mice, cell proliferation is nicely detected in lymph nodes, but not in other organs showing the reliability of this baseclick method.

Our EdU in vivo cell proliferation Kits provide a superior alternative to BrdU and [3H]-thymidine assays for detection of cell proliferation in whole animals. In principal, EdU (5-ethynyl-2’-deoxyuridine), a thymidine analog, is fed to animals. As it is incorporated into DNA during active DNA synthesis and shows a clickable functionality, the content of new cells can be assessed after harvesting the tissue of interest. Detection can then be performed after reaction with the dye of choice using fluorescent microscopy.

The DetectPro Kits combine all the advantages of their very popular predecessors – the EdU Click Kits – with a brand new fluorescence enhancer system. This makes them just as easy to handle and as reliable, while showing outstanding efficiency and greatly enhanced signal and sensitivity.

Product CodeNamePack SizeDownloadsPriceBuy
BCK-EdU488-1EdU Cell Proliferation Kit for Imaging (EdU-Click 488) + EdU (5 mg)1 kit £402.00

BCK-EdU555-1EdU Cell Proliferation Kit for Imaging (EdU-Click 555) + EdU (5 mg)1 kit £402.00

BCK-EdU594-1EdU Cell Proliferation Kit for Imaging (EdU-Click 594) + EdU (5 mg)1 kit£402.00

BCK-EdU647-1EdU Cell Proliferation Kit for Imaging (EdU-Click 647) + EdU (5 mg)1 kit £402.00

BCK-EdUPro-IM488Sensitive EdU DetectPro Cell Proliferation Kit 488 (100 assays)1 Kit £417.00

BCK-EdUPro-IM647Sensitive EdU DetectPro Cell Proliferation Kit 647 (100 assays)1 Kit £439.00

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Product CodeNameShort descriptionDownloadsPriceBuy
BCK488-IV-IM-SIn vivo Imaging Kit EdU Click 488 + EdU (50 mg)1 kit £455.00

BCK488-IV-IM-MIn vivo Imaging Kit EdU Click 488 + EdU (500 mg)1 kit £955.00

BCK488-IV-IM-LIn vivo Imaging Kit EdU Click 488 + EdU (1000 mg)1 kit £1,392.00

BCK555-IV-IM-SIn vivo Imaging Kit EdU Click 555 + EdU (50 mg)1 kit £455.00

BCK555-IV-IM-MIn vivo Imaging Kit EdU Click 555 + EdU (500 mg)1 kit £955.00

BCK555-IV-IM-LIn vivo Imaging Kit EdU Click 555 + EdU (1000 mg)1 kit £1,392.00

BCK594-IV-IM-SIn vivo Imaging Kit EdU Click 594 + EdU (50 mg)1 kit£455.00

BCK594-IV-IM-MIn vivo Imaging Kit EdU Click 594 + EdU (500 mg)1 kit £955.00

BCK594-IV-IM-LIn vivo Imaging Kit EdU Click 594 + EdU (1000 mg)1 kit £1,392.00

BCK647-IV-IM-SIn vivo Imaging Kit EdU Click 647 + EdU (50 mg)1 kit £455.00

BCK647-IV-IM-MIn vivo Imaging Kit EdU Click 647 + EdU (500 mg)1 kit £955.00

BCK647-IV-IM-LIn vivo Imaging Kit EdU Click 647 + EdU (1000 mg)1 kit £1,392.00

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